The Duesenberg Straight Eight debuted in the late 1920s, with production starting in late 1921 after redesigns overseen by Fred Duesenberg in Indianapolis. It was the first U.S. car with a straight-eight engine and featured pioneering hydraulic brakes.

The Model A, crafted from 1921 to 1926, reached a top speed of 71 mph, claiming the title of America's inaugural series-production straight-eight vehicle.